Cisplatin-induced apoptosis

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August undefined, 2024

WebMar 9, 2024 · Lentinan can alleviate cisplatin-induced apoptosis of HK-2 human kidney proximal tubular cells and disrupt renal function in mice. The mechanism is related to the activation of the NRF2-ARE signaling pathway and decrease in intracellular ROS. Moreover, lentinan also inhibits the proliferation of HeLa and A549 cells . WebNov 7, 2024 · Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected …

Cisplatin-induced apoptosis in auditory cells: role of death recep…

WebJul 1, 1999 · Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines We have assessed in detail the effect of cisplatin-activated programmed cell death in the cisplatin-sensitive human ovarian cancer cell line A2780 and two drug-resistant … WebCisplatin forms inter- and intrastrand crosslinked DNA adducts and its cytotoxicity is mediated by propagation of DNA damage recognition signals to downstream pathways … greenhorn flowers evanston wyoming

Cisplatin induces protective autophagy through activation of …

WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was … WebCisplatin (cis-diamminedichloroplatinum; CDDP) 1 is a potent inducer of growth arrest and/or apoptosis in most cell types and is among the most effective and widely used chemotherapeutic agents employed for … WebVarious recent studies have investigated (GLP-1R) role in cardiovascular diseases due to antiapoptotic and antioxidant effects. The current study aimed to investigate the curative … fly america open skies

Cisplatin-induced apoptosis is enhanced by hypoxia and by

Cisplatin-induced apoptosis proceeds by caspase-3 …

WebApr 14, 2024 · Since HK-2-cells-generated-Abs, both by cisplatin or upon UV light exposure, can induce apoptosis in HK-2 cells, the purpose of this work was to study their metabolome and therein find the molecular features which help us to unravel the mechanisms of that phenomenon. WebVarious recent studies have investigated (GLP-1R) role in cardiovascular diseases due to antiapoptotic and antioxidant effects. The current study aimed to investigate the curative role of semaglutide's against cisplatin- induced cardiotoxicity and its relation to mitochondrial functions, dynamics, biogenesis, apoptosis, and redox status pathways. fly american or deltaWebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent necroptosis in … fly ami

"WebFor example, cisplatin induces apoptosis via ROS overgeneration in osteosarcoma MG-63 cell line , methotrexate triggers cell death by upregulating ROS production in osteosarcoma U-2 OS cells , and carvacrol triggers ROS-dependent apoptosis to suppress proliferation in prostate cancer and lung adenocarcinoma cell lines . " - Cisplatin-induced apoptosis

Cisplatin-induced apoptosis

MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin ...

WebSilencing STING by siRNA rescued HaCaT cells from UVB or cisplatin-induced apoptosis. NF-κB, one of the major downstream components of STING pathway, which usually regulates the classical STING apoptotic pathway, was translocated to nucleus in the HaCaT cells irradiated with UVB. This translocation was attenuated by STING silencing. WebCisplatin-induced nuclear DNA (nDNA) damage in dorsal root ganglion (DRG) neurons has been thoroughly investigated. Cisplatin covalently binds to nuclear DNA (nDNA) inducing DNA damage and apoptosis. Cisplatin-induced DNA damage up-regulates p53 and induces cell cycle changes in DRG neurons.

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WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … WebOct 16, 2006 · Cisplatin is a broad-spectrum anticancer drug that is also widely used in experimental studies on DNA damage-induced apoptosis. Induction of apoptosis within 24–48 hr requires cisplatin concentrations that are …

Web2-ME promoted the growth inhibitory and apoptosis-inducing effects of platinum-based agents in SKOV3 ovarian cancer cells and promoted the mRNA and protein expression of Bax, thereby, increasing the Bax/Bcl-2 expression ratio and activating the mitochondrial apoptosis pathway. 8 PDF WebOct 15, 2001 · cis-platinum(II) (cis-diammine dichloroplatinum; cisplatin) is a potent antitumor compound that is widely used for the treatment of many malignancies. An important side-effect of cisplatin is nephrotoxicity, which results from injury to renal tubular epithelial cells and can be manifested as either …

WebNov 7, 2024 · Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected by cisplatin but its relevance in cell death induction is scarcely investigated. WebThis study investigated non-targeted metabolomic analysis on ABs and medium from apoptotic HK-2 cells induced with cisplatin or exposure to UV light. ... We did not mean that these differences will result in differences in the extension of apoptosis induced by ABs because we knew from our previous work published in Biochimica et Biophysica …

WebMoreover, DSF sensitized ovarian cancer cells to cisplatin treatment and enhanced cisplatin-induced apoptosis, both in SDC and MDC. In the present studies, we have used a quantitative method to determine synergism or antagonism of DSF in chemotherapy drug treatment. Three pairs of two-drug combinations and a three-drug combination were …

WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in … greenhorn fishing jobs fly a migWebDec 12, 2024 · Cisplatin is one of the most generally used and highly effective chemotherapy drugs for the treatment of various types of human cancer, such as testicular, ovarian, head and neck, bladder, bone,... flyamerica flight finderWebJan 17, 2024 · Cisplatin is a well-known chemotherapeutic drug. It is one of the most effective anticancer agents and is widely used for the treatment of several types of tumors. However, side effects in normal tissues and organs, such as nephrotoxicity that induces apoptosis in epithelial cells in the kidney, limit the use of cisplatin. green horn food truck menuWebThe chemotherapeutic drug cisplatin elicits cytotoxicity causing renal tubular cell death, but its executing mechanisms of action are versatile and elusive. Here, we show that cisplatin induces renal tubular cell apoptosis and ferroptosis by … fly amman to adelaideWebJul 1, 1999 · Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer … fly a military jetWebCisplatin-induced apoptosis in BUMPT cells. (A) BUMPT cells were untreated or treated with 40 μ mol/L cisplatin for 20 h. Cell morphology was recorded by phase- contrast microscopy (10 × ). (B)... fly amman to cyprus