WebThe incidence of lymphomas is increased in people living with HIV (PLWH). Aggressive B-cell non-Hodgkin lymphomas (NHLs) are the most common and are considered an AIDS-defining cancer (ADC). Although Hodgkin lymphoma (HL) is not considered an ADC, its incidence is also increased in PLWH. Among all HIV-related lymphomas (HRL), the … WebPurpose: Nasal type extranodal natural killer/T-cell lymphoma (ENKTL) can be associated with hemophagocytic lymphohistiocytosis (NK/T-LAHLH), which is a rare and fatal disease with no effective therapy. We evaluated whether etoposide + dexamethasone-based chemotherapy regimens might be useful for treating NK/T-LAHLH. Methods: This …
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WebDec 21, 2024 · Corticosteroids are important anti-inflammatory drugs for HLH, with dexamethasone having higher concentrations in the cerebrospinal fluid and a longer half-life in the CNS than prednisone. 42 Importantly, etoposide can compensate for the … Web1 day ago · Methotrexate, etoposide, dexamethasone, pegaspargase (MESA) with sandwiched radiotherapy is known to be effective for early-stage extranodal natural-killer/T-cell lymphoma, nasal type (NKTCL). We explored the efficacy and safety of reduced-intensity, non-intravenous etoposide, dexamethasone, pegaspargase (ESA) with …
WebUsed for etoposide, vinca alkaloids, taxanes (eg, paclitaxel, docetaxel), ifosfamide, hyperosmolar agents, hypoosmolar agents, agents containing propylene glycol, acidic and alkaline agents, and agents that are refractory to absorption (eg, propofol, lipids) ... None or dexamethasone 8 mg twice daily for 14 days: Vinblastine Vincristine WebNov 13, 2024 · We developed a novel regimen that combines ibrutinib with temozolomide, etoposide, doxil, dexamethasone, and rituximab (TEDDi-R) for relapsed and refractory PCNSL. TEDDi-R achieved durable remissions in chemotherapy-refractory PCNSL (Roschewski et al. ASH 2024), but has been associated with opportunistic infections, …
WebCHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) is a commonly used regimen in lymphoma, but yields poor results in ENKTL patients due to the overexpression of P-glycoprotein in ENKTL. 3–5 Recently, L-asparaginase (L-asp)-based chemotherapy such as SMILE (L-asparaginase, methotrexate, ifosfamide, etoposide and … WebMar 25, 2024 · vomiting, constipation, fever. trouble swallowing, or. unusual or unpleasant taste in the mouth. Serious side effects of Etoposide include: sudden chest pain or discomfort, wheezing, dry cough or hack; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum ), purple or red pinpoint spots under the skin; vision problems;
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WebJun 6, 2024 · The HLH-94 protocol drastically improved the nearly uniformly fatal outcome in pediatric HLH to a long-term survival >50%. 3 The HLH-94 protocol consists of corticosteroids, typically dexamethasone, cyclosporine A (CSA), intrathecal therapy, and etoposide, to delete activated T cells and suppress inflammatory cytokine production . 6 … diane hegarty ossining nyWebJul 25, 2024 · Etoposide side effects. Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).. Etoposide may cause serious side effects. Call your doctor at once if you … diane hegarty-laveyWebDec 4, 2024 · Abstract. In this study, our aim was to compare the efficacy and toxicity profiles of gemcitabine, cisplatin, and dexamethasone (GDP) and ifosfamide, carboplatin, and etoposide (ICE) regimens in the salvage treatment of relapsed/refractory lymphoma. A total of 110 patients with refractory/relapsed classical Hodgkin lymphoma (n = 22) or non ... diane helferich obituaryWebWeeks DEXAMETHASONE and ETOPOSIDE (given on alternate weeks) 9 - 52 ODD number weeks DEXAMETHASONE 10 mg/m2 PO once daily for 3 days EVEN number weeks ETOPOSIDE 150 mg/m2 in 1000mL 0.9% sodium chloride IV infusion over 2 hours ONCE weekly CICLOSPORIN 3 mg/kg PO BD: Starting at week 9. Measure baseline … diane hemingway npiWebSep 19, 2024 · Subjects will receive venetoclax combined with dexamethasone and etoposide for 8 weeks.The safety was evaluated once a week, and the efficacy was evaluated once every 2 weeks. Overall response rate will be evaluated at 8 weeks. cite book online mlaWebEtoposide also causes DNA damage through inhibition of topoisomerase II and activation of oxidation-reduction reactions to produce derivatives that bind directly to DNA. ... rifampin, dexamethasone, carbamazepine, phenobarbital, St. John’s Wort, etc) ↓ etoposide effect: ↑ metabolism of etoposide: Caution; dose of etoposide may require ... diane hemme obituaryWebJan 21, 2024 · While current regimens are often platinum-based, we present single-center data on 70 patients with RRMM who were treated with cyclophosphamide, etoposide, and dexamethasone (CED) after a median of four lines of therapy. An overall response rate of 52% was achieved after 1–6 cycles, with 23% of patients having a very good partial … diane heinz kansas city mo