Intrinsic subtypes 乳腺癌
WebFeb 15, 2024 · With the development of various targeted therapies in breast cancer, detection of biomarkers for predicting treatment efficacy gains importance. With the definition of intrinsic subtypes, breast cancer has paved the way for personalized treatment. Already known and recently recognized targets play an important role both in … WebWhile accumulating evidences suggest that intrinsic subtypes provide clinically relevant information beyond clinical surrogates, it is imperative to establish whether the current …
Intrinsic subtypes 乳腺癌
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WebJul 1, 2011 · Since TNBCs are largely considered basal-like, we correlated each of the 386 TNBC tumor profiles to the intrinsic gene set centroids of the 5 molecular subtypes, as previously described . Tumors were assigned to 1 of the molecular subtypes based on the highest correlation coefficient between each TNBC expression profile and the 5 … WebMay 28, 2024 · The intrinsic subtypes provided along with the data resource were referred to as the conventional intrinsic subtype. Among the 712 cases, the consistency between the conventional intrinsic subtype ...
WebAug 19, 2014 · Here, we evaluated the molecular features and survival outcomes of the intrinsic subtypes within HER2+ breast cancer. Methods: We interrogated The Cancer Genome Atlas (n = 495) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) datasets (n = 1730) of primary breast cancers for molecular … WebMay 21, 2014 · Identification of five molecular ‘intrinsic’ subtypes by hierarchical clustering of 115 tumour tissues and seven non-malignant tissues. a Scaled-down representation of …
WebOct 1, 2012 · As noted above, Perou’s group was the first to provide a molecular classification for breast cancer. Using a cDNA microarray of 38 breast cancer cases, the … WebDec 4, 2014 · Technologies to measure gene expression in a massively parallel fashion have facilitated a more complete molecular understanding of breast cancer (BC) and a …
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WebApr 29, 2016 · Seminal studies in the early 2000s led to the development of a molecular-based classification of breast cancer as well as several multigene prognostic signatures for breast cancer patients ( 1, 2).The ‘intrinsic’ gene subtypes (ie, luminal A, luminal B, human epidermal growth factor receptor 2 [HER2]–enriched and basal-like) ( 3-5 ) have … cyst on an ovaryWebOct 7, 2024 · Since their discovery in 2000 (1, 2), gene expression–based molecular subtypes of breast cancer have been independently confirmed and widely accepted ().To facilitate clinical implementation, gene expression assays mimicking the original subtyping algorithm have been developed, with perhaps the most well-known and well-spread … binding of isaac controlled tearsWebJan 4, 2024 · Background Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear. Methods Among … binding of isaac controls controller