Phosphoproteome of resting human platelets

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August undefined, 2024

WebNov 5, 2024 · We analyzed the phosphoproteome of equivalent amounts of protein extracted from isolated resting platelets from 12 obese patients (4 pools of 3 individuals each) and … WebMarcus K, Moebius J, Meyer H E (2003) Differential analysis of phosphorylated proteins in resting and thrombin-stimulated human platelets. Anal Bioanal Chem 376 , 973–993. …

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WebTo gain a deeper insight into platelet function, we analyzed the phosphoproteome of resting platelets and identified 564 phosphorylation sites from more than 270 proteins, of which … WebJul 9, 2024 · Analysis of the platelet phosphoproteome revealed 2,516 phosphorylation sites, of which 453 were regulated by Gsα-PKA. Common changes in the patients were: (1) a joint panel of upregulated and downregulated phosphopeptides; (2) overall PKA dependency of the upregulated phosphopeptides; (3) links to key platelet function pathways. how can food help the brain

Immobility-associated thromboprotection is conserved across …

WebTo gain a deeper insight into platelet function, we analyzed the phosphoproteome of resting platelets and identified 564 phosphorylation sites from more than 270 proteins, of which … WebApr 12, 2024 · Spindle-shaped platelets contained a small number of granules and did not exhibit active adhesion, while the structure of their membranes was normal after 1-2 days of storage and abnormalities appeared during subsequent storage. Morphofunctional properties of spindle-shaped platelets under normal and pathological conditions were … WebFor proteomics (global, phospho, N termini) analysis, platelet samples (5.0 × 10 8 /ml) were collected into 1 volume of lysis buffer (50 m m Tris, 1% SDS, 150 m m NaCl, 1 tablet PhosStop/7 ml, pH 7.8) ( 15. ). Lysed samples were immediately frozen and … how can food harm people

Combined Quantification of the Global Proteome, …

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WebTo gain a deeper insight into platelet function, we analyzed the phosphoproteome of resting platelets and identified 564 phosphorylation sites from more than 270 proteins, of which … WebFeb 23, 2011 · Most proteomic efforts can be grouped into several distinct categories: (1) cataloging the spectrum of proteins that comprise the normal, resting (quiescent) platelet proteome, (2)... how can food labels be confusingWebstream of aIIbb3 in human platelets, leading to an interaction with Grb2 and SHIP-1. Keywords: Dok-1, Dok-3, G6b-B, G6f, platelet-proteomics, ... MS analysis of the aIIbb3 phosphoproteome reveals novel signaling proteins ... adherent (control, resting platelets) and ﬁbrinogen adherent platelets using an anti-phosphotyrosine monoclonal antibody how can food packaging damage the environment

"WebOct 27, 2009 · The identified platelet proteins were used to generate a comprehensive platelet protein-protein interaction network that computationally recapitulated known … " - Phosphoproteome of resting human platelets

Phosphoproteome of resting human platelets

WebDec 1, 2006 · Phosphoproteomics of human platelets: A quest for novel activation pathways - ScienceDirect Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics Volume … Web1 day ago · Credit: Tobias Petzold, Ludwig-Maximilians University Munich. Bears in hibernation as well as paraplegic people spend months or even years lying almost motionless while avoiding dangerous blood ...

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WebNov 12, 2024 · (A) Workflow summary for multiplexed, quantitative phosphoproteomics analysis of resting vs CRP-XL-activated platelets. Blood was drawn from n = 5 healthy … WebDec 20, 2007 · Sigma-Aldrich offers abstracts and full-text articles by [René P Zahedi, Urs Lewandrowski, Julia Wiesner, Stefanie Wortelkamp, Jan Moebius, Claudia Schütz, Ulrich Walter, Stepan Gambaryan, Albert Sickmann].

WebJan 6, 2014 · Human platelets isolated by gel filtration were incubated with the oxidized phospholipid KODA-PC, or PLPC (as control). Platelets were then lysed and the proteins … WebJul 9, 2024 · In our previous work, we have used protein mass spectrometry techniques for quantitative analysis of the global platelet proteome 18 and of the iloprost-induced platelet phosphoproteome 19. In the ...

WebThe mass spectrometry-based platelet phosphoproteome was combined with site-specific phosphorylation/ dephosphorylation information from the Human Protein Database (HPRD), enhanced with data from PhosphoSite and complemented by bioinformatical sequence analysis for site-specific kinase predictions.

WebNov 5, 2024 · The Phosphoproteomic Analysis Identified More Than 1500 Phosphosites We analyzed the phosphoproteome of equivalent amounts of protein extracted from isolated resting platelets from 12 obese patients (4 pools of 3 individuals each) and 12 age- and gender-matched lean controls by liquid chromatography-mass spectrometry-tandem …

Webof integrin aIIbb3 activation in resting platelets but also provides an improved model for analysis and discovery of PPI dynamics and signaling pathways in the future. Citation: Qureshi AH, Chaoji V, Maiguel D, Faridi MH, Barth CJ, et al. (2009) Proteomic and Phospho-Proteomic Profile of Human Platelets in Basal, Resting State: how many people are born every monthWebDec 19, 2007 · Europe PMC is an archive of life sciences journal literature. how can football be made saferWebSharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 ... Zahedi RP, et al. (2008) Phosphoproteome of resting human platelets. J Proteome Res 7, 526-34 how can food preservation extend shelf lifeWebJan 1, 2011 · Most proteomic efforts can be grouped into several distinct categories: (1) cataloging the spectrum of proteins that comprise the normal, resting (quiescent) platelet proteome, (2) characterizing proteins released from activated (functional) platelets, and (3) identifying specific platelet subproteomes (i.e., membrane ( 10 – 12 ), phosphorylation … how can food get contaminatedWebSince important and initial steps of platelet activation and aggregation are regulated by phosphorylation events, a comprehensive study aimed at the characterization of phosphorylation-driven signaling cascades might lead to the identification of new target proteins for clinical research. how can food labels help youWebDec 19, 2007 · To gain a deeper insight into platelet function, we analyzed the phosphoproteome of resting platelets and identified 564 phosphorylation sites from … how can food waste be turned into energyWebLa Biblioteca Virtual en Salud es una colección de fuentes de información científica y técnica en salud organizada y almacenada en formato electrónico en la Región de América Latina y el Caribe, accesible de forma universal en Internet de modo compatible con las bases internacionales. how can foods served at a buffet stay hot