WebbDirectly reprogramming fibroblasts into cardiomyocytes improves cardiac function in the infarcted heart. However, the low efficacy of this approach hinders clinical applications. Unlike the adult mammalian heart, the neonatal heart has an intrinsic regenerative capacity. Consequently, we hypothesized that birth imposes fundamental changes on … TNNT2 gene is transiently expressed in embryonic and neonatal skeletal muscles in both avian and mammalian organisms. When TNNT2 is expressed in neonatal skeletal muscle, the alternative splicing of exon 5 exhibits a synchronized regulation to that in the heart in a species-specific manner. Visa mer Cardiac muscle troponin T (cTnT) is a protein that in humans is encoded by the TNNT2 gene. Cardiac TnT is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of … Visa mer Cardiac TnT is a 35.9 kDa protein composed of 298 amino acids. Cardiac TnT is the largest of the three troponin subunits (cTnT, troponin I (TnI), troponin C (TnC)) on the actin thin filament of cardiac muscle. The structure of TnT is asymmetric; the … Visa mer Three homologous genes have evolved in vertebrates encoding three muscle type- specific isoforms of TnT. Each of the TnT isoform genes is … Visa mer Mammalian TNNT2 gene contains 14 constitutive exons and 3 alternatively spliced exons. Exons 4 and 5 encoding the N-terminal variable … Visa mer As part of the Troponin complex, the function of cTnT is to regulate muscle contraction. The N-terminal region of TnT that strongly binds actin most likely moves with Visa mer Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with restrictive and dilated cardiomyopathy. Transcripts for this gene undergo Visa mer Phosphorylation Ser2 of cTnT at the N terminus is constitutively phosphorylated by unknown mechanisms. cTnT has been found to be phosphorylated by … Visa mer

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WebbTNNT2 (Troponin T2, cardiac type) - mediates muscle contraction MYH7 (Myosin heavy chain 7) - expressed in slow type I muscle fibers TNNI3 - heart muscle TNNT2 - heart muscle MYH7 - skeletal muscle Adipose & soft tissue FABP4 (Fatty acid binding protein 4) - involved in fatty acid uptake, transport, and metabolism WebbThe pan-cardiac marker cardiac troponin T (TNNT2), encoding a key sarcomeric protein, is expressed highly across both of hiPSC-derived cardiomyocyte products, highlighting the purity of our cardiomyocyte differentiation. Axol Human iPSC-Derived Ventricular Cardiomyocytes were cultured in ... seek initiative

The human proteome in tissue specific - The Human Protein Atlas

WebbInherited heart conditions are caused by a change or mutation in one gene or in a number of genes. Types of inherited heart conditions include cardiomyopathies, arrhythmias, thoracic aortic aneurysms and dissections, and familial hypercholesterolemia. One of the most important reasons for identifying your risk early for a hereditary heart ... WebbRecommendations for multimodality cardiovascular imaging of patients with hypertrophic cardiomyopathy: an update from the American Society of Echocardiography, in collaboration with the American Society of Nuclear Cardiology, the Society for Cardiovascular Magnetic Resonance, and the Society of Cardiovascular Computed … WebbTNNT2 mutation is associated with a range of cardiac diseases, including dilated cardiomyopathy (DCM). However, the mechanisms underlying the development of DCM … seek insurance company